The campus is mainly located in south-eastern Rome, featuring renovated industrial buildings transformed into modern facilities equipped with advanced technologies, laboratories, and green areas for university life. Roma Tre includes 13 Departments, four of which have been awarded as "Departments of Excellence" by the Italian Ministry of University and Research, recognised among the top 15 in Italy.

With over 80 bachelor's and master's degrees, 27 PhD programmes, various courses in English, and numerous double and joint degrees, Roma Tre offers a dynamic international environment with 1,467 students in exchange programmes.