THE GENERAL MICROBIOLOGY COURSE IS INTENDED TO PROVIDE A SOLID KNOWLEDGE BACKGROUND ON:
1) THE STRUCTURE AND FUNCTION OF THE PROKARYOTIC CELL; 2) THE MECHANISMS OF REPLICATION, EXCHANGE, RECOMBINATION AND EXPRESSION OF DNA IN BACTERIA; 3) THE NUTRITION, GROWTH AND METABOLISM OF BACTERIA; 4) THE STRUCTURAL, GENETIC, AND METABOLIC DIVERSITY IN BACTERIA; 5) THE ANTIMICROBIAL DRUGS AND THE CONTROL OF MICROBIAL GROWTH;6) THE CONCEPT OF BACTERIAL SPECIES AND THE EVOLUTION AND THE TAXONOMY OF BACTERIA; 7) THE BASIC PRINCIPLES OF MICROBIAL ECOLOGY; 8) THE PRINCIPLES OF MOLECULAR VIROLOGY OF BACTERIOPHAGES AND ANIMAL VIRUSES 9) THE INTERACTIONS BETWEEN BACTERIA, VIRUSES AND HIGHER ORGANISMS.
1) THE STRUCTURE AND FUNCTION OF THE PROKARYOTIC CELL; 2) THE MECHANISMS OF REPLICATION, EXCHANGE, RECOMBINATION AND EXPRESSION OF DNA IN BACTERIA; 3) THE NUTRITION, GROWTH AND METABOLISM OF BACTERIA; 4) THE STRUCTURAL, GENETIC, AND METABOLIC DIVERSITY IN BACTERIA; 5) THE ANTIMICROBIAL DRUGS AND THE CONTROL OF MICROBIAL GROWTH;6) THE CONCEPT OF BACTERIAL SPECIES AND THE EVOLUTION AND THE TAXONOMY OF BACTERIA; 7) THE BASIC PRINCIPLES OF MICROBIAL ECOLOGY; 8) THE PRINCIPLES OF MOLECULAR VIROLOGY OF BACTERIOPHAGES AND ANIMAL VIRUSES 9) THE INTERACTIONS BETWEEN BACTERIA, VIRUSES AND HIGHER ORGANISMS.
teacher profile teaching materials
STRUCTURE AND FUNCTION OF THE BACTERIAL CELL. MICROBIAL DIVERSITY. THE DISCOVERY OF MICROBES AND MAIN HISTORICAL EXPERIMENTS. THE CELL WALL OF BACTERIA AND ARCHAEA. THE PEPTIDOGLYCAN: STRUCTURE, FUNCTION, BIOGENESIS. THE STAIN PROPERTIES OF BACTERIA. THE PROKARYOTIC CELL MEMBRANE AND THE MEMBRANE TRANSPORT SYSTEMS. CYTOPLASMIC STRUCTURES (ORGANELLES AND INCLUSIONS) AND THE EXTRA-CYTOPLASMIC STRUCTURES (CAPSULES, PILI, FIMBRIA, FLAGELLA). STRUCTURE AND ORGANIZATION OF THE PROKARYOTIC GENOME. REGULATION OF GENE EXPRESSION IN BACTERIA. THE SPORE STRUCTURE AND REGULATION OF SPORULATION. BACTERIAL CHEMOTAXIS AND OTHER TAXES. NUTRITION, CULTURE AND METABOLISM OF BACTERIA. CHEMOLITOTROPHY. BACTERIAL CELL DIVISION. MICROBIAL GROWTH AND FACTORS AFFECTING GROWTH. CONTROL OF MICROBIAL GROWTH BY CHEMICAL AND PHYSICAL METHODS; STERILIZATION AND DISINFECTION. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. ANTIBIOTIC RESISTANCE. HOST-PARASITE INTERACTIONS AND PATHOGENICITY FACTORS. EXOTOXINS AND ENDOTOXIN. INTRACELLULAR PARASITISM.
MICROBIAL EVOLUTION AND SYSTEMATICS. TAXONOMY AND MAIN TAXONOMIC UNITS IN PROKARYOTES. THE SPECIES CONCEPT IN BACTERIA. THE GENERAL PHYLOGENY OF BACTERIA. METHODS FOR INVESTIGATION OF BACTERIAL PHYLOGENY AND SPECIES IDENTIFICATION. GENOTYPIC ANALYSES. THE ARCHAEA: STRUCTURAL, FUNCTIONAL, METABOLIC AND EVOLUTIONARY CHARACTERISTICS. HYPERTHERMOPHILIC, METHANOGENIC AND HALOPHILIC ARCHAEA. BIODIVERSITY IN PROKARYOTES. OUTLINE OF MICROBIAL BIOTECHNOLOGIES.
USEFULL WEB SITES: https://viralzone.expasy.org/; http://www.microbeworld.org/microbes/; http://gsbs.utmb.edu/microbook/toc.htm; http://www.bact.wisc.edu/microtextbook/
Other recommended textbooks available at the Roma Tre University library:
- PRESCOTT/HARLEY/KLEIN'S, MICROBIOLOGY
- MURRAY, ROSENTHAL, PFALLER, MEDICAL MICROBIOLOGY,
- CANN ALAN J.,PRINCIPLES OF MOLECULAR VIROLOGY,
- EDWARD K. WAGNER E MARTINEZ J. HEWLETT – BASIC VIROLOGY –BLACKWELL SCIENCE
Teachers will also provide technical and experimental protocols for the laboratory exercises.
Programme
MODULE 1 BACTERIOLOGYSTRUCTURE AND FUNCTION OF THE BACTERIAL CELL. MICROBIAL DIVERSITY. THE DISCOVERY OF MICROBES AND MAIN HISTORICAL EXPERIMENTS. THE CELL WALL OF BACTERIA AND ARCHAEA. THE PEPTIDOGLYCAN: STRUCTURE, FUNCTION, BIOGENESIS. THE STAIN PROPERTIES OF BACTERIA. THE PROKARYOTIC CELL MEMBRANE AND THE MEMBRANE TRANSPORT SYSTEMS. CYTOPLASMIC STRUCTURES (ORGANELLES AND INCLUSIONS) AND THE EXTRA-CYTOPLASMIC STRUCTURES (CAPSULES, PILI, FIMBRIA, FLAGELLA). STRUCTURE AND ORGANIZATION OF THE PROKARYOTIC GENOME. REGULATION OF GENE EXPRESSION IN BACTERIA. THE SPORE STRUCTURE AND REGULATION OF SPORULATION. BACTERIAL CHEMOTAXIS AND OTHER TAXES. NUTRITION, CULTURE AND METABOLISM OF BACTERIA. CHEMOLITOTROPHY. BACTERIAL CELL DIVISION. MICROBIAL GROWTH AND FACTORS AFFECTING GROWTH. CONTROL OF MICROBIAL GROWTH BY CHEMICAL AND PHYSICAL METHODS; STERILIZATION AND DISINFECTION. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. ANTIBIOTIC RESISTANCE. HOST-PARASITE INTERACTIONS AND PATHOGENICITY FACTORS. EXOTOXINS AND ENDOTOXIN. INTRACELLULAR PARASITISM.
MICROBIAL EVOLUTION AND SYSTEMATICS. TAXONOMY AND MAIN TAXONOMIC UNITS IN PROKARYOTES. THE SPECIES CONCEPT IN BACTERIA. THE GENERAL PHYLOGENY OF BACTERIA. METHODS FOR INVESTIGATION OF BACTERIAL PHYLOGENY AND SPECIES IDENTIFICATION. GENOTYPIC ANALYSES. THE ARCHAEA: STRUCTURAL, FUNCTIONAL, METABOLIC AND EVOLUTIONARY CHARACTERISTICS. HYPERTHERMOPHILIC, METHANOGENIC AND HALOPHILIC ARCHAEA. BIODIVERSITY IN PROKARYOTES. OUTLINE OF MICROBIAL BIOTECHNOLOGIES.
Core Documentation
BROCK, BIOLOGY OF MICROORGANISMS, EDS: M. T. MADIGAN - J. M. MARTINKO - D. A. STAHL - D. P. CLARK integrate virology and antimicrobial immunity using N. J. Dimmock, A. J. Easton, K. N. Leppard - Introduction to Modern Virology - Seventh edition 2016 -Wiley BlackwellUSEFULL WEB SITES: https://viralzone.expasy.org/; http://www.microbeworld.org/microbes/; http://gsbs.utmb.edu/microbook/toc.htm; http://www.bact.wisc.edu/microtextbook/
Other recommended textbooks available at the Roma Tre University library:
- PRESCOTT/HARLEY/KLEIN'S, MICROBIOLOGY
- MURRAY, ROSENTHAL, PFALLER, MEDICAL MICROBIOLOGY,
- CANN ALAN J.,PRINCIPLES OF MOLECULAR VIROLOGY,
- EDWARD K. WAGNER E MARTINEZ J. HEWLETT – BASIC VIROLOGY –BLACKWELL SCIENCE
Teachers will also provide technical and experimental protocols for the laboratory exercises.
Type of delivery of the course
lectures and laboratory exercisesType of evaluation
this year, for the first time, it has been given the optional possibility to carry out two written tests after the first two modules and at the end of the course respectively related to the "biology and genetics of prokaryotes and archaea" and to "virology and antimicrobial immunity "with a mark out of thirty that, in case of sufficiency, could be verbalized by averaging between the two tests or improved through the oral test on the examination dates established for the academic year.