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Prof. DANTE ROTILI

Contributo in Rivista

• 1,2,4-Oxadiazoles in medicinal chemistry: trends of the last years, ROTILI, DANTE, , 2025Link identifier #identifier_person_166993-1 Dettaglio
• An Amazing 30-Year Journey around the DABO Family: A Medicinal Chemistry Lesson on a Versatile Class of Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors, ROTILI, DANTE, , 2025Link identifier #identifier_person_83780-2 Dettaglio
• An improved multiplex RT–quantitative PCR assay can reveal sex-specific activity of transmission-blocking drugs on ex vivo gametocytes from Plasmodium falciparum asymptomatic infections, ROTILI, DANTE, , 2025Link identifier #identifier_person_189778-3 Dettaglio
• Bromodomain and Extra-Terminal Family Proteins BRD2, BRD3, and BRD4 Contribute to H19-Dependent Transcriptional Regulation of Cell Adhesion Molecules, Modulating Metastatic Dissemination Program in Prostate Cancer, ROTILI, DANTE, , 2025Link identifier #identifier_person_124294-4 Dettaglio
• Development of C646‐Based Proteolysis Targeting Chimeras Degraders of the Lysine Acetyltransferases CBP and p300, ROTILI, DANTE, , 2025Link identifier #identifier_person_115130-5 Dettaglio
• Duplexed CeTEAM drug biosensors reveal determinants of PARP inhibitor selectivity in cells, ROTILI, DANTE, , 2025Link identifier #identifier_person_49828-6 Dettaglio
• GDF15-GFRAL signaling drives weight loss and lipid metabolism in mouse model of amyotrophic lateral sclerosis, ROTILI, DANTE, , 2025Link identifier #identifier_person_166394-7 Dettaglio
• Native mass spectrometry for proximity-inducing compounds: a new opportunity for studying chemical-induced protein modulation, ROTILI, DANTE, , 2025Link identifier #identifier_person_181858-8 Dettaglio
• Optimization of Lipoplexes Functionalized with a Sialic Acid Mimetic (F9-PEG) to Target the C1858T PTPN22 Variant for Preclinical Assessment of a Novel Immunotherapy in Endocrine Autoimmunity, ROTILI, DANTE, , 2025Link identifier #identifier_person_162982-9 Dettaglio
• Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of Schistosoma mansoni, ROTILI, DANTE, , 2025Link identifier #identifier_person_25344-10 Dettaglio
• (Heteroarylmethyl)benzoic Acids as a New Class of Bacterial Cystathionine γ-Lyase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling, ROTILI, DANTE, , 2024Link identifier #identifier_person_20736-11 Dettaglio
• A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection, ROTILI, DANTE, , 2024Link identifier #identifier_person_29646-12 Dettaglio
• Activation and inhibition of sirtuins: From bench to bedside, ROTILI, DANTE, , 2024Link identifier #identifier_person_118653-13 Dettaglio
• Enhancing sensitivity of triple‐negative breast cancer to DNA‐damaging therapy through chemical inhibition of the m6A methyltransferase METTL3, ROTILI, DANTE, , 2024Link identifier #identifier_person_59878-14 Dettaglio
• M6A reduction relieves FUS-associated ALS granules, ROTILI, DANTE, , 2024Link identifier #identifier_person_55263-15 Dettaglio
• Off-Target Inhibition of Human Dihydroorotate Dehydrogenase (hDHODH) Highlights Challenges in the Development of Fat Mass and Obesity-Associated Protein (FTO) Inhibitors, ROTILI, DANTE, , 2024Link identifier #identifier_person_134463-16 Dettaglio
• Prognostic Impact of H19/Cell Adhesion Molecules Circuitry on Prostate Cancer Biopsy, ROTILI, DANTE, , 2024Link identifier #identifier_person_66332-17 Dettaglio
• Quinoline-based compounds can inhibit diverse enzymes that act on DNA, ROTILI, DANTE, , 2024Link identifier #identifier_person_46217-18 Dettaglio
• Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity, ROTILI, DANTE, , 2024Link identifier #identifier_person_124650-19 Dettaglio
• Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1, ROTILI, DANTE, , 2024Link identifier #identifier_person_69642-20 Dettaglio
• Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer, ROTILI, DANTE, , 2024Link identifier #identifier_person_71902-21 Dettaglio
• The α-tubulin acetyltransferase ATAT1: structure, cellular functions, and its emerging role in human diseases, ROTILI, DANTE, , 2024Link identifier #identifier_person_63183-22 Dettaglio
• Transmission-Blocking Strategies for Malaria Eradication: Recent Advances in Small-Molecule Drug Development, ROTILI, DANTE, , 2024Link identifier #identifier_person_199286-23 Dettaglio
• Uracil‐ and Pyridine‐Containing HDAC Inhibitors Displayed Cytotoxicity in Colorectal and Glioblastoma Cancer Stem Cells, ROTILI, DANTE, , 2024Link identifier #identifier_person_144104-24 Dettaglio
• Antihistamines, phenothiazine-based antipsychotics, and tricyclic antidepressants potently activate pharmacologically relevant human carbonic anhydrase isoforms II and VII, ROTILI, DANTE, , 2023Link identifier #identifier_person_56198-25 Dettaglio
• BET Protein Inhibitor JQ1 Ameliorates Experimental Peritoneal Damage by Inhibition of Inflammation and Oxidative Stress, ROTILI, DANTE, , 2023Link identifier #identifier_person_79446-26 Dettaglio
• Chemically Diverse S. mansoni HDAC8 Inhibitors Reduce Viability in Worm Larval and Adult Stages, ROTILI, DANTE, , 2023Link identifier #identifier_person_12575-27 Dettaglio
• Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile-Specific DNA Adenine Methyltransferase, ROTILI, DANTE, , 2023Link identifier #identifier_person_126320-28 Dettaglio
• Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection, ROTILI, DANTE, , 2023Link identifier #identifier_person_143390-29 Dettaglio
• First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8, ROTILI, DANTE, , 2023Link identifier #identifier_person_45254-30 Dettaglio
• GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design, ROTILI, DANTE, , 2023Link identifier #identifier_person_169500-31 Dettaglio
• HDAC1-3 inhibition increases SARS-CoV-2 replication and productive infection in lung mesothelial and epithelial cells, ROTILI, DANTE, , 2023Link identifier #identifier_person_82212-32 Dettaglio
• Hydroxamate-based compounds are potent inhibitors of Toxoplasma gondii HDAC biological activity, ROTILI, DANTE, , 2023Link identifier #identifier_person_158656-33 Dettaglio
• METTL3 from Target Validation to the First Small-Molecule Inhibitors: A Medicinal Chemistry Journey, ROTILI, DANTE, , 2023Link identifier #identifier_person_19201-34 Dettaglio
• Molecular insights into RmcA-mediated c-di-GMP consumption: Linking redox potential to biofilm morphogenesis in Pseudomonas aeruginosa, ROTILI, DANTE, , 2023Link identifier #identifier_person_2214-35 Dettaglio
• Native mass spectrometry-directed drug discovery: Recent advances in investigating protein function and modulation, ROTILI, DANTE, , 2023Link identifier #identifier_person_197513-36 Dettaglio
• Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells, ROTILI, DANTE, , 2023Link identifier #identifier_person_83540-37 Dettaglio
• Pharmacological targeting of CBP/p300 drives a redox/autophagy axis leading to senescence-induced growth arrest in non-small cell lung cancer cells, ROTILI, DANTE, , 2023Link identifier #identifier_person_196693-38 Dettaglio
• Pyrimidine thioethers: A novel class of antidepressant agents, endowed with anxiolytic, performance enhancing and nootropic activity, ROTILI, DANTE, , 2023Link identifier #identifier_person_143043-39 Dettaglio
• Role of SIRT3 in Microgravity Response: A New Player in Muscle Tissue Recovery, ROTILI, DANTE, , 2023Link identifier #identifier_person_91810-40 Dettaglio
• Simultaneous administration of EZH2 and BET inhibitors inhibits proliferation and clonogenic ability of metastatic prostate cancer cells, ROTILI, DANTE, , 2023Link identifier #identifier_person_21095-41 Dettaglio
• SIRT6 Protects Against Lipopolysaccharide-Induced Inflammation in Human Pulmonary Lung Microvascular Endothelial Cells, ROTILI, DANTE, , 2023Link identifier #identifier_person_103457-42 Dettaglio
• State of the art of carbonic anhydrase activators, ROTILI, DANTE, , 2023Link identifier #identifier_person_36649-43 Dettaglio
• Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile-Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence, ROTILI, DANTE, , 2023Link identifier #identifier_person_74339-44 Dettaglio
• The role of structural biology in the design of sirtuin activators, ROTILI, DANTE, , 2023Link identifier #identifier_person_179428-45 Dettaglio
• 90 Y-DOTA-Nimotuzumab: Synthesis of a Promising β− Radiopharmaceutical, VENDITTI, IOLE, , 2022Link identifier #identifier_person_67879-46 Dettaglio
• A potent HDAC inhibitor blocks Toxoplasma gondii tachyzoite growth and profoundly disrupts parasite gene expression, ROTILI, DANTE, , 2022Link identifier #identifier_person_101514-47 Dettaglio
• Biochemical Functions and Clinical Characterizations of the Sirtuins in Diabetes-Induced Retinal Pathologies, ROTILI, DANTE, , 2022Link identifier #identifier_person_51753-48 Dettaglio
• Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni, ROTILI, DANTE, , 2022Link identifier #identifier_person_155699-49 Dettaglio
• Histone lysine demethylase inhibition reprograms prostate cancer metabolism and mechanics, ROTILI, DANTE, , 2022Link identifier #identifier_person_144201-50 Dettaglio
• Hydrophilic Gold Nanoparticles as Anti-PD-L1 Antibody Carriers: Synthesis and Interface Properties, VENDITTI, IOLE; BATTOCCHIO, CHIARA; IUCCI, GIOVANNA; CARLINI, LAURA, , 2022Link identifier #identifier_person_93013-51 Dettaglio
• Modulation of Virulence-Associated Traits in Aspergillus fumigatus by BET Inhibitor JQ1, ROTILI, DANTE, , 2022Link identifier #identifier_person_118973-52 Dettaglio
• Multimodal evaluation of 19F-BPA internalization in pancreatic cancer cells for boron capture and proton therapy potential applications, ROTILI, DANTE, , 2022Link identifier #identifier_person_73783-53 Dettaglio
• Neuroprotective Effects of PARP Inhibitors in Drosophila Models of Alzheimer’s Disease, ROTILI, DANTE, , 2022Link identifier #identifier_person_157654-54 Dettaglio
• Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models, ROTILI, DANTE, , 2022Link identifier #identifier_person_6057-55 Dettaglio
• Sirtuin modulators: past, present, and future perspectives, ROTILI, DANTE, , 2022Link identifier #identifier_person_65736-56 Dettaglio
• The Nitrobenzoxadiazole Derivative NBDHEX Behaves as Plasmodium falciparum Gametocyte Selective Inhibitor with Malaria Parasite Transmission Blocking Activity, ROTILI, DANTE, , 2022Link identifier #identifier_person_63007-57 Dettaglio
• Therapeutic Potential and Activity Modulation of the Protein Lysine Deacylase Sirtuin 5, ROTILI, DANTE, , 2022Link identifier #identifier_person_12157-58 Dettaglio
• Transcriptomic and genomic studies classify NKL54 as a histone deacetylase inhibitor with indirect influence on MEF2-dependent transcription, ROTILI, DANTE, , 2022Link identifier #identifier_person_12496-59 Dettaglio
• Anti-influenza A virus activity and structure–activity relationship of a series of nitrobenzoxadiazole derivatives, ROTILI, DANTE, , 2021Link identifier #identifier_person_139730-60 Dettaglio
• Emerging Therapeutic Potential of SIRT6 Modulators, ROTILI, DANTE, , 2021Link identifier #identifier_person_54304-61 Dettaglio
• First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53, TRISCIUOGLIO, DANIELA; ROTILI, DANTE, , 2021Link identifier #identifier_person_124714-62 Dettaglio
• Mass spectrometry enables the discovery of inhibitors of an LPS transport assembly via disruption of protein–protein interactions, ROTILI, DANTE, , 2021Link identifier #identifier_person_115358-63 Dettaglio
• Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression, ROTILI, DANTE, , 2021Link identifier #identifier_person_179465-64 Dettaglio
• Regulatory Interplay between miR-181a-5p and Estrogen Receptor Signaling Cascade in Breast Cancer, ROTILI, DANTE, , 2021Link identifier #identifier_person_183457-65 Dettaglio
• SIRT5 Inhibition Induces Brown Fat-Like Phenotype in 3T3-L1 Preadipocytes, ROTILI, DANTE, , 2021Link identifier #identifier_person_41760-66 Dettaglio
• The Two-Faced Role of SIRT6 in Cancer, ROTILI, DANTE, , 2021Link identifier #identifier_person_63338-67 Dettaglio
• CDK9 as a Valuable Target in Cancer: From Natural Compounds Inhibitors to Current Treatment in Pediatric Soft Tissue Sarcomas, ROTILI, DANTE, , 2020Link identifier #identifier_person_13052-68 Dettaglio
• Characterization of water-soluble esters of nitrobenzoxadiazole-based GSTP1-1 inhibitors for cancer treatment, ROTILI, DANTE, , 2020Link identifier #identifier_person_16231-69 Dettaglio
• From PARP1 to TNKS2 Inhibition: A Structure-Based Approach, ROTILI, DANTE, , 2020Link identifier #identifier_person_107641-70 Dettaglio
• Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes, ROTILI, DANTE, , 2020Link identifier #identifier_person_61611-71 Dettaglio
• Lysine Acetyltransferase Inhibitors From Natural Sources, ROTILI, DANTE, , 2020Link identifier #identifier_person_43476-72 Dettaglio
• Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni, ROTILI, DANTE, , 2020Link identifier #identifier_person_189018-73 Dettaglio
• Radioguided surgery with β − radiation in pancreatic Neuroendocrine Tumors: a feasibility study, VENDITTI, IOLE, , 2020Link identifier #identifier_person_187730-74 Dettaglio
• Recent Advances in Epigenetic Proteolysis Targeting Chimeras (Epi-PROTACs), ROTILI, DANTE, , 2020Link identifier #identifier_person_37347-75 Dettaglio
• Sirt4: A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer, ROTILI, DANTE, , 2020Link identifier #identifier_person_89280-76 Dettaglio
• Sirtuin modulators: where are we now? A review of patents from 2015 to 2019, ROTILI, DANTE, , 2020Link identifier #identifier_person_11566-77 Dettaglio
• Targeting histone acetylation/deacetylation in parasites: an update (2017–2020), ROTILI, DANTE, , 2020Link identifier #identifier_person_125157-78 Dettaglio
• The Pan-Sirtuin Inhibitor MC2494 Regulates Mitochondrial Function in a Leukemia Cell Line, ROTILI, DANTE, , 2020Link identifier #identifier_person_131842-79 Dettaglio
• Tranylcypromine‐Based LSD1 Inhibitors: Structure‐Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation, ROTILI, DANTE, , 2020Link identifier #identifier_person_51738-80 Dettaglio
• Comparison of the effects of synthetic and plant-derived mTOR regulators on healthy human ovarian cells, ROTILI, DANTE, , 2019Link identifier #identifier_person_116158-81 Dettaglio
• Effect of α-methoxy substitution on the anti-HIV activity of dihydropyrimidin-4(3 H)-ones, ROTILI, DANTE, , 2019Link identifier #identifier_person_23961-82 Dettaglio
• Effects of glutathione transferase-targeting nitrobenzoxadiazole compounds in relation to PD-L1 status in human melanoma cells, ROTILI, DANTE, , 2019Link identifier #identifier_person_188426-83 Dettaglio
• Enzymatic and Biological Characterization of Novel Sirtuin Modulators against Cancer, ROTILI, DANTE, , 2019Link identifier #identifier_person_79034-84 Dettaglio
• Epigenetic polypharmacology: a new frontier for epi-drug discovery, ROTILI, DANTE, , 2019Link identifier #identifier_person_198081-85 Dettaglio
• Gold Nanoparticles and Nanorods in Nuclear Medicine: A Mini Review, BATTOCCHIO, CHIARA; VENDITTI, IOLE, , 2019Link identifier #identifier_person_41797-86 Dettaglio
• H19-Dependent Transcriptional Regulation of β3 and β4 Integrins Upon Estrogen and Hypoxia Favors Metastatic Potential in Prostate Cancer, ROTILI, DANTE, , 2019Link identifier #identifier_person_111492-87 Dettaglio
• Histone deacetylase inhibitors exert anti-tumor effects on human adherent and stem-like glioma cells 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis, ROTILI, DANTE, , 2019Link identifier #identifier_person_40548-88 Dettaglio
• Identification of novel quinazoline derivatives as potent antiplasmodial agents, ROTILI, DANTE, , 2019Link identifier #identifier_person_194316-89 Dettaglio
• Inhibition of histone demethylases LSD1 and UTX regulates ERα signaling in breast cancer, ROTILI, DANTE, , 2019Link identifier #identifier_person_126899-90 Dettaglio
• Structure-reactivity relationships on substrates and inhibitors of the lysine deacylase sirtuin 2 from schistosoma mansoni (SmSirt2), ROTILI, DANTE, , 2019Link identifier #identifier_person_10025-91 Dettaglio
• Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis, ROTILI, DANTE, , 2019Link identifier #identifier_person_59701-92 Dettaglio
• α,γ-Diketocarboxylic acids and their esters act as carbonic anhydrase IX and XII selective inhibitors, ROTILI, DANTE, , 2019Link identifier #identifier_person_175829-93 Dettaglio
• Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches, ROTILI, DANTE, , 2018Link identifier #identifier_person_183465-94 Dettaglio
• KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2, ROTILI, DANTE, , 2018Link identifier #identifier_person_64574-95 Dettaglio
• Lysine acetyltransferase inhibitors: structure-activity relationships and potential therapeutic implications, ROTILI, DANTE, , 2018Link identifier #identifier_person_37014-96 Dettaglio
• Mass spectrometry characterization of DOTA-Nimotuzumab conjugate as precursor of an innovative β − tracer suitable in radio-guided surgery, VENDITTI, IOLE, , 2018Link identifier #identifier_person_125597-97 Dettaglio
• Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells, TRISCIUOGLIO, DANIELA; ROTILI, DANTE, , 2018Link identifier #identifier_person_26386-98 Dettaglio
• RIP1-HAT1-SirT complex identification and targeting in treatment and prevention of cancer, ROTILI, DANTE, , 2018Link identifier #identifier_person_4953-99 Dettaglio
• A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability, ROTILI, DANTE, , 2017Link identifier #identifier_person_198938-100 Dettaglio
• Corrigendum: Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma, ROTILI, DANTE, , 2017Link identifier #identifier_person_176089-101 Dettaglio
• Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features, ROTILI, DANTE, , 2017Link identifier #identifier_person_166242-102 Dettaglio
• Development of 1,2,4-oxadiazoles as potent and selective inhibitors of the human deacetylase sirtuin 2: structure-activity relationship, X-ray crystal structure, and anticancer activity, ROTILI, DANTE, , 2017Link identifier #identifier_person_59285-103 Dettaglio
• Feasibility of beta-particle radioguided surgery for a variety of ânuclear medicineâ radionuclides, VENDITTI, IOLE, , 2017Link identifier #identifier_person_193568-104 Dettaglio
• Lysine deacetylase inhibitors in parasites: past, present, and future perspectives, ROTILI, DANTE, , 2017Link identifier #identifier_person_195935-105 Dettaglio
• Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma, ROTILI, DANTE, , 2017Link identifier #identifier_person_134356-106 Dettaglio
• Structural basis of sirtuin 6 activation by synthetic small molecules, ROTILI, DANTE, , 2017Link identifier #identifier_person_183925-107 Dettaglio
• The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis, ROTILI, DANTE, , 2017Link identifier #identifier_person_133151-108 Dettaglio
• The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor, ROTILI, DANTE, , 2017Link identifier #identifier_person_26222-109 Dettaglio
• Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity, ROTILI, DANTE, , 2017Link identifier #identifier_person_40652-110 Dettaglio
• Y3+ embedded in polymeric nanoparticles: Morphology, dimension and stability of composite colloidal system, VENDITTI, IOLE, , 2017Link identifier #identifier_person_39400-111 Dettaglio
• At long last potent and selective KDM5 inhibitors, ROTILI, DANTE, , 2016Link identifier #identifier_person_149223-112 Dettaglio
• c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition, ROTILI, DANTE, , 2016Link identifier #identifier_person_157342-113 Dettaglio
• Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells, ROTILI, DANTE; TRISCIUOGLIO, DANIELA, , 2016Link identifier #identifier_person_101976-114 Dettaglio
• Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features, ROTILI, DANTE, , 2016Link identifier #identifier_person_57979-115 Dettaglio
• Sirtuin functions and modulation: from chemistry to the clinic, ROTILI, DANTE, , 2016Link identifier #identifier_person_179386-116 Dettaglio
• The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases, ROTILI, DANTE, , 2016Link identifier #identifier_person_150046-117 Dettaglio
• Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells, ROTILI, DANTE, , 2016Link identifier #identifier_person_32827-118 Dettaglio
• A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib, ROTILI, DANTE, , 2015Link identifier #identifier_person_108361-119 Dettaglio
• A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts, ROTILI, DANTE, , 2015Link identifier #identifier_person_161278-120 Dettaglio
• Enzyme kinetics and inhibition of histone acetyltransferase KAT8, ROTILI, DANTE, , 2015Link identifier #identifier_person_114987-121 Dettaglio
• Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells, ROTILI, DANTE, , 2015Link identifier #identifier_person_145125-122 Dettaglio
• Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells, ROTILI, DANTE, , 2015Link identifier #identifier_person_3863-123 Dettaglio
• SIRT5 regulation of ammonia-induced autophagy and mitophagy, ROTILI, DANTE, , 2015Link identifier #identifier_person_191171-124 Dettaglio
• Synthesis and structure-activity relationship of new cytotoxic agents targeting human glutathione-S-transferases, ROTILI, DANTE, , 2015Link identifier #identifier_person_110760-125 Dettaglio
• Targeting lysine deacetylases (KDACs) in parasites, ROTILI, DANTE, , 2015Link identifier #identifier_person_108734-126 Dettaglio
• Context-Selective Death of Acute Myeloid Leukemia Cells Triggered by the Novel Hybrid Retinoid-HDAC Inhibitor MC2392, ROTILI, DANTE, , 2014Link identifier #identifier_person_102344-127 Dettaglio
• Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: Enzyme and cellular studies, ROTILI, DANTE, , 2014Link identifier #identifier_person_186830-128 Dettaglio
• Exploring the role of 2-chloro-6-fluoro substitution in 2-alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: effects in HIV-1-infected cells and in HIV-1 reverse transcriptase enzymes, ROTILI, DANTE, , 2014Link identifier #identifier_person_29508-129 Dettaglio
• I kappa B kinase (IKK)-epsilon targets interferon regulatory factor 1 in activated T lymphocytes, ROTILI, DANTE, , 2014Link identifier #identifier_person_145815-130 Dettaglio
• Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities, ROTILI, DANTE, , 2014Link identifier #identifier_person_173595-131 Dettaglio
• Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity, ROTILI, DANTE, , 2014Link identifier #identifier_person_80832-132 Dettaglio
• Quinoline-based p300 histone acetyltransferase inhibitors with pro-apoptotic activity in human leukemia U937 cells, ROTILI, DANTE, , 2014Link identifier #identifier_person_165184-133 Dettaglio
• Sirtuin modulators control reactive gliosis in an in vitro model of alzheimer's disease, ROTILI, DANTE, , 2014Link identifier #identifier_person_96345-134 Dettaglio
• Inhibition of Class I Histone Deacetylases Unveils a Mitochondrial Signature and Enhances Oxidative Metabolism in Skeletal Muscle and Adipose Tissue, ROTILI, DANTE, , 2013Link identifier #identifier_person_70840-135 Dettaglio
• PARP-1 Modulates Amyloid Beta Peptide-Induced Neuronal Damage, ROTILI, DANTE, , 2013Link identifier #identifier_person_123515-136 Dettaglio
• 2-(Alkyl/aryl)amino-6-benzylpyrimidin-4(3H)-ones as inhibitors of wild-type and mutant HIV-1: enantioselectivity studies, ROTILI, DANTE, , 2012Link identifier #identifier_person_143941-137 Dettaglio
• 6-(Arylmethyl)pyrimidin-4(3H)-ones: Anthology and prospects of highly efficient anti-HIV agents, ROTILI, DANTE, , 2012Link identifier #identifier_person_78369-138 Dettaglio
• An Analog of BIX-01294 Selectively Inhibits a Family of Histone H3 Lysine 9 Jumonji Demethylases, ROTILI, DANTE, , 2012Link identifier #identifier_person_168521-139 Dettaglio
• Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells, ROTILI, DANTE, , 2012Link identifier #identifier_person_55768-140 Dettaglio
• Carprofen Analogues as Sirtuin Inhibitors: Enzyme and Cellular Studies, ROTILI, DANTE, , 2012Link identifier #identifier_person_191322-141 Dettaglio
• Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells, ROTILI, DANTE, , 2012Link identifier #identifier_person_33734-142 Dettaglio
• p300/CBP-associated factor selectively regulates the extinction of conditioned fear, ROTILI, DANTE, , 2012Link identifier #identifier_person_157332-143 Dettaglio
• A Photoreactive Small-Molecule Probe for 2-Oxoglutarate Oxygenases, ROTILI, DANTE, , 2011Link identifier #identifier_person_61920-144 Dettaglio
• Biological Effects of MC2050, a Quinazoline-Based PARP-1 Inhibitor, in Human Neuroblastoma and EBV-Positive Burkitt's Lymphoma Cells, ROTILI, DANTE, , 2011Link identifier #identifier_person_88807-145 Dettaglio
• Diarylpyrimidine-Dihydrobenzyloxopyrimidine Hybrids: New, Wide-Spectrum Anti-HIV-1 Agents Active at (Sub)-Nanomolar Level, ROTILI, DANTE, , 2011Link identifier #identifier_person_118218-146 Dettaglio
• Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3'-C-methyladenosine in leukaemia cells, ROTILI, DANTE, , 2011Link identifier #identifier_person_125074-147 Dettaglio
• Modulation of cell differentiation, proliferation, and tumor growth by dihydrobenzyloxopyrimidine non-nucleoside reverse transcriptase inhibitors, ROTILI, DANTE, , 2011Link identifier #identifier_person_116539-148 Dettaglio
• Photoactivable peptides for identifying enzyme-substrate and protein-protein interactions, ROTILI, DANTE, , 2011Link identifier #identifier_person_140394-149 Dettaglio
• Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: Coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile, ROTILI, DANTE, , 2011Link identifier #identifier_person_106489-150 Dettaglio
• Targeting histone demethylases: A new avenue for the fight against cancer, ROTILI, DANTE, , 2011Link identifier #identifier_person_66596-151 Dettaglio
• Characterization of Sirtuin Inhibitors in Nematodes Expressing a Muscular Dystrophy Protein Reveals Muscle Cell and Behavioral Protection by Specific Sirtinol Analogues, ROTILI, DANTE, , 2010Link identifier #identifier_person_107738-152 Dettaglio
• HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation, ROTILI, DANTE, , 2010Link identifier #identifier_person_20350-153 Dettaglio
• Identification of Tri- and Tetracyclic Pyrimidinediones as Sirtuin Inhibitors, ROTILI, DANTE, , 2010Link identifier #identifier_person_35766-154 Dettaglio
• Nitric oxide determines mesodermic differentiation of mouse embryonic stem cells by activating class IIa histone deacetylases: potential therapeutic implications in a mouse model of hindlimb ischemia, ROTILI, DANTE, , 2010Link identifier #identifier_person_106690-155 Dettaglio
• Proteomic profile of differentially expressed plasma proteins from dystrophic mice and following suberoylanilide hydroxamic acid treatment, ROTILI, DANTE, , 2010Link identifier #identifier_person_79800-156 Dettaglio
• The histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces cardiac arrhythmias in dystrophic mice, ROTILI, DANTE, , 2010Link identifier #identifier_person_169572-157 Dettaglio
• The specific character of the reaction of derivatives of 2-thioxo-2,3-dihydropyrimidin-4(1H)-one with iodomethane and alkyl chloromethyl sulfides, ROTILI, DANTE, , 2010Link identifier #identifier_person_46681-158 Dettaglio
• Chiral HPLC separation and absolute configuration of novel S-DABO derivatives, ROTILI, DANTE, , 2009Link identifier #identifier_person_147832-159 Dettaglio
• Histone deacetylase inhibitors and neurodegenerative disorders: Holding the promise, ROTILI, DANTE, , 2009Link identifier #identifier_person_183785-160 Dettaglio
• Identification of 4-hydroxyquinolines inhibitors of p300/CBP histone acetyltransferases, ROTILI, DANTE, , 2009Link identifier #identifier_person_146276-161 Dettaglio
• Non-cancer uses of histone deacetylase inhibitors: effects on infectious diseases and β-hemoglobinopathies, ROTILI, DANTE, , 2009Link identifier #identifier_person_127035-162 Dettaglio
• Reactions of 6-benzyl-5-methyl-2-(methylsulfanyl)pyrimidin-4(3H)-one with aliphatic and aliphatic-aromatic amines, ROTILI, DANTE, , 2009Link identifier #identifier_person_172332-163 Dettaglio
• Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect, ROTILI, DANTE, , 2009Link identifier #identifier_person_92935-164 Dettaglio
• Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes, ROTILI, DANTE, , 2009Link identifier #identifier_person_130127-165 Dettaglio
• Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence, ROTILI, DANTE, , 2009Link identifier #identifier_person_128735-166 Dettaglio
• Stereoselective synthesis of 2-substituted 6-[1-(2,6-difluorophenyl)ethyl]-5-methylpyrimidin-4(3H)-ones, ROTILI, DANTE, , 2009Link identifier #identifier_person_154760-167 Dettaglio
• 5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile, ROTILI, DANTE, , 2008Link identifier #identifier_person_132112-168 Dettaglio
• Class II-selective histone deacetylase inhibitors. Part 2: Alignment-independent GRIND 3-D QSAR, homology and docking studies, ROTILI, DANTE, , 2008Link identifier #identifier_person_18976-169 Dettaglio
• Histone deacetylase inhibitors and hemoglobin F induction in beta-thalassemia, ROTILI, DANTE, , 2008Link identifier #identifier_person_120712-170 Dettaglio
• Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases, ROTILI, DANTE, , 2008Link identifier #identifier_person_195012-171 Dettaglio
• Nitric oxide modulates chromatin folding in human endothelial cells via protein phosphatase 2A activation and class II histone deacetylases nuclear shuttling, ROTILI, DANTE, , 2008Link identifier #identifier_person_83213-172 Dettaglio
• Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: Histone deacetylase inhibition and in-cell activities, ROTILI, DANTE, , 2008Link identifier #identifier_person_122548-173 Dettaglio
• Substrate-induced stable enzyme-inhibitor complex formation allows tight binding of novel 2-aminopyrimidin-4(3H)-ones to drug-resistant HIV-1 reverse transcriptase mutants, ROTILI, DANTE, , 2008Link identifier #identifier_person_51102-174 Dettaglio
• Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans, ROTILI, DANTE, , 2007Link identifier #identifier_person_131275-175 Dettaglio
• Histone deacetylase inhibitors may reduce pathogenicity and virulence in Candida albicans, ROTILI, DANTE, , 2007Link identifier #identifier_person_95769-176 Dettaglio
• Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia, ROTILI, DANTE, , 2007Link identifier #identifier_person_154752-177 Dettaglio
• Novel pyrrole-containing histone deacetylase inhibitors endowed with cytodifferentiation activity, ROTILI, DANTE, , 2007Link identifier #identifier_person_119804-178 Dettaglio
• Slow-, tight-binding HIV-1 reverse transcriptase non-nucleoside inhibitors highly active against drug-resistant mutants, ROTILI, DANTE, , 2007Link identifier #identifier_person_55474-179 Dettaglio
• Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains, ROTILI, DANTE, , 2007Link identifier #identifier_person_168434-180 Dettaglio
• 6-Alkylthio-4-[1-(2,6-difluorophenyl)alkyl]-1H-[1,3,5]triazin-2-ones (ADATs): Novel Regulators of Cell Differentiation and Proliferation, ROTILI, DANTE, , 2006Link identifier #identifier_person_139738-181 Dettaglio
• Analytical and semipreparative high performance liquid chromatography separation of stereoisomers of novel 3,4-dihydropyrimidin-4(3H)-one derivatives on the immobilised amylose-based Chiralpack IA chiral stationary phase, ROTILI, DANTE, , 2006Link identifier #identifier_person_81441-182 Dettaglio
• Identification of small molecules inhibitors of GCN5 histone acetyltransferase activity, ROTILI, DANTE, , 2006Link identifier #identifier_person_67410-183 Dettaglio
• One-Pot, High Yielding Synthesis of Novel Dihydrothiazolo[3,2-a]pyrimidinones, ROTILI, DANTE, , 2006Link identifier #identifier_person_182803-184 Dettaglio
• Small-Molecule Inhibitors of Histone Acetyltransferase Activity: Identification and Biological Properties, ROTILI, DANTE, , 2006Link identifier #identifier_person_174670-185 Dettaglio
• Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors, ROTILI, DANTE, , 2006Link identifier #identifier_person_89945-186 Dettaglio
• 6-[1-(2,6-difluorophenyl)ethyl]pyrimidinones antagonize cell proliferation and induce cell differentiation by inhibiting (a nontelomeric) endogenous reverse transcriptase, ROTILI, DANTE, , 2005Link identifier #identifier_person_169160-187 Dettaglio
• A novel Gcn5p inhibitor represses cell growth, gene transcription and histone acetylation in budding yeast, ROTILI, DANTE, , 2005Link identifier #identifier_person_935-188 Dettaglio
• Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides, ROTILI, DANTE, , 2005Link identifier #identifier_person_3375-189 Dettaglio
• Exploring the connection unit in the HDAC inhibitor pharmacophore model: Novel uracil-based hydroxamates, ROTILI, DANTE, , 2005Link identifier #identifier_person_78-190 Dettaglio
• Histone Deacetylation in Epigenetics: An Attractive Target for Anticancer Therapy, ROTILI, DANTE, , 2005Link identifier #identifier_person_116283-191 Dettaglio
• Discovery of (Aryloxo propenyl)pyrrolyl Hydroxyamides as Selective Inhibitors of Class IIa Histone Deacetylase Homologue HD1-A, ROTILI, DANTE, , 2003Link identifier #identifier_person_10662-192 Dettaglio

Libro

• Link identifier #identifier_person_106769-193Dettaglio

Contributo in volume e atti di convegno

• ROTILI, DANTE, HAT inhibitors in cancer therapy, pp. 51 80, 2020 Link identifier #identifier_person_24191-194Dettaglio
• ROTILI, DANTE, DNA Methylation: Biological Implications and Modulation of Its Aberrant Dysregulation, pp. 295 331, 2019 Link identifier #identifier_person_111602-195Dettaglio
• ROTILI, DANTE, Histone Acetyltransferase Enzymes: From Biological Implications to Most Relevant Inhibitors, pp. 1 30, 2019 Link identifier #identifier_person_190535-196Dettaglio
• ROTILI, DANTE, Sirtuins as drug targets, pp. 185 200, 2019 Link identifier #identifier_person_194949-197Dettaglio
• ROTILI, DANTE, Evaluation of histone deacetylases as drug targets in Huntington's disease models, vol. 2, 2010 Link identifier #identifier_person_154183-198Dettaglio