The aim of the course is to deepen the increasingly close relationship between criminal procedural law and the use of technological tools to ascertain the crime. With this in mind, after examining the fundamental institutes of criminal procedure, the student will be directed towards a comparison, also critical, with the grafting of digital and computer technologies into today's criminal justice system. To this end, the most recent legislative and jurisprudential innovations in the field of technical-scientific evidence, digital evidence and artificial intelligence will be examined in depth, which now constitute an essential background for the legal professional. Particular attention will be devoted to the theme of procedural guarantees that are in danger of changing in the face of similar and new challenges of technological progress applied to the procedural verification of liability for criminal acts.