The course helps the students to increase their capabilities in analyzing the mechanical systems that are commonly employed in industrial and non-industrial applications. The students will be able to understand how the mechanical systems work and how to improve their performances during ordinary working. For this reason, the modeling and the design of the mechanical systems are studied in details, and many fundamental aspects of mechanics are illustrated, such as, topology, kinematic and dynamic of multibody systems, tribology, lubrication, mechanical efficiency, power flows, and mechanical vibrations. These fields are applied to particular systems such as transmissions, gears, brakes and cam-follower mechanisms.