The Integrated Manufacturing Systems Course provides students in the fifth year of the master's degree with the basic elements for the use of numerical control in material subtraction processing. The course includes a first part dedicated to the deepening of machining by chip removal, with particular reference to the aspects of cutting mechanics as well as the tool sizing criteria for the most common turning, milling and drilling operations. In this context, the aspects concerning the problems of tool wear and Taylor's law will not be neglected. The Course also provides a second part dedicated to the optimization models of numerical control processes according to the criteria of maximum economy and maximum productivity. In addition, the strategies for the closed and numerical resolution of the main optimization models of numerical control work will be proposed. Finally, the first elements will be provided for the use of SW CAD / CAM in mechanical design, with specific reference to machining with numerical control machines.