20402518 - TOXICOLOGY

The course has the purpose of providing the student with fundamental knowledge on the basic principles of toxicology.
In particular, the involvements of toxicity arising form the voluntary use or from the involuntary exposure of the human organism to substances of different nature will be analyzed.
The description of mechanisms through which the substances in question produce their effects, constituting a cardinal point of discipline, will pursue the objective to supply the interpretative basis of the adverse effects suffered in apparatus and organs from different categories of products.
Such knowledge will allow the student to acquire professional capacities useful specifications in laboratories of experimental and analytical survey and to carry out professional activity in the field of pharmacy-toxicologic to protect the safety of the environment, foodstuffs, cosmetic products and pharmaceuticals, summary of natural origin.

TREZZA VIVIANA

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Mutuazione: 20402518 TOSSICOLOGIA in Biologia per la ricerca molecolare, cellulare e fisiopatologica LM-6 N0 TREZZA VIVIANA

Programma

GENERAL PRINCIPLES. AIMS AND FIELDS OF TOXICOLOGY. CLASSIFICATION OF TOXIC AGENTS. MECHANISMS OF MOLECULAR AND CELL TOXICITY. RISK EVALUATION. TOXICOKINETICS: ABSORPTION, DISTRIBUTION, METABOLISM AND EXCRETION OF TOXIC AGENTS. ADVERSE DRUG REACTIONS, DRUG INTERACTIONS AND PRINCIPLES OF PHARMACOVIGILANCE. ANTIDOTES AND THEIR CLASSIFICATION. EXPERIMENTAL EVALUATION OF TOXIC EFFECTS IN IN VITRO AND IN VIVO MODELS AND DATA EXTRAPOLATION. SYSTEM AND ORGAN TOXICOLOGY. DEVELOPMENTAL AND FEEDING TOXICOLOGY. CLASSES OF TOXIC COMPOUNDS: METALS, PHYTODRUGS, NATURAL TOXINS. PSYCHOACTIVE AND DOPING DRUGS.

Testi Adottati

CASARETT & DOULL'S “ESSENTIALS OF TOXICOLOGY”, SECOND EDITION, MCGRAW HILL

Power-point files of the lessons will be provided. The files are also available on the MOODLE platform
To get an appointment with the Professor, email to: viviana.trezza@uniroma3.it


Modalità Valutazione

Two intercourse written assessments will be made, consisting of open questions and multiple-choice questions. The evaluation of each test will be in 30/30. Students who will get a score of at least 18 in each test will pass the exam, with a score corresponding to the average score of the two tests . Alternatively, students may also decide to have a single oral exam on the entire program of the course, with an overall evaluation in 30/30.