The course aims to provide students with fundamental knowledge on the basic principles of toxicology. In particular, the toxicodynamic and toxicokinetic mechanisms that are behind the toxic effects produced by different natural and synthesized xenobiotics, and the process of evaluation of toxicological risks will be analyzed. This knowledge will allow students to acquire specific professional skills useful in experimental and analytical research laboratories and to carry out professional activities in the pharmaco-toxicological field to protect the safety of the environment, food, cosmetic products and drugs, of both synthetic and natural origin.
teacher profile teaching materials
Power-point files of the lessons will be provided. The files are also available on the MOODLE platform
To get an appointment with the Professor, email to: viviana.trezza@uniroma3.it
Programme
GENERAL PRINCIPLES. AIMS AND FIELDS OF TOXICOLOGY. CLASSIFICATION OF TOXIC AGENTS. MECHANISMS OF MOLECULAR AND CELL TOXICITY. RISK EVALUATION. TOXICOKINETICS: ABSORPTION, DISTRIBUTION, METABOLISM AND EXCRETION OF TOXIC AGENTS. ADVERSE DRUG REACTIONS, DRUG INTERACTIONS AND PRINCIPLES OF PHARMACOVIGILANCE. ANTIDOTES AND THEIR CLASSIFICATION. EXPERIMENTAL EVALUATION OF TOXIC EFFECTS IN IN VITRO AND IN VIVO MODELS AND DATA EXTRAPOLATION. SYSTEM AND ORGAN TOXICOLOGY. DEVELOPMENTAL AND FEEDING TOXICOLOGY. CLASSES OF TOXIC COMPOUNDS: METALS, PHYTODRUGS, NATURAL TOXINS. PSYCHOACTIVE AND DOPING DRUGS.Core Documentation
CASARETT & DOULL'S “ESSENTIALS OF TOXICOLOGY”, SECOND EDITION, MCGRAW HILLPower-point files of the lessons will be provided. The files are also available on the MOODLE platform
To get an appointment with the Professor, email to: viviana.trezza@uniroma3.it
Type of evaluation
Two intercourse written assessments will be made, consisting of open questions and multiple-choice questions. The evaluation of each test will be in 30/30. Students who will get a score of at least 18 in each test will pass the exam, with a score corresponding to the average score of the two tests . Alternatively, students may also decide to have a single oral exam on the entire program of the course, with an overall evaluation in 30/30.