Deepening the knowledge about animal viruses (origins, classification, replicative strategies, virulence, immunoevasion mechanisms) and their applications (antiviral vaccines, viral vectors for gene expression, oncolytic viruses).
teacher profile teaching materials
Adopted text book:
- N. J. Dimmock, A. J. Easton, K. N. Leppard - Introduction to Modern Virology - Seventh edition 2016 -Wiley Blackwell - ISBN 978-1-119-97810-7
- Leonard Norkin – Virology: Molecular Biology and Pathogenesis - ASM (American Society for Microbiology) Press (this text book is more detailed)
Students are received at the end of the lessons or by appointment via email (elisabetta.affabris@uniroma3.it).
Mutuazione: 20410321 VIROLOGIA ANIMALE GENERALE ED APPLICATA in Biologia per la ricerca molecolare, cellulare e fisiopatologica LM-6 AFFABRIS ELISABETTA
Programme
The course describes and compares the replication cycles of different animal viruses that infect vertebrate hosts to gain insight into: origin of viruses, structure, evolution, virus-cell interactions, host defense mechanisms and strategies of viral immunoevasion, methods of detection, identification and titration, antiviral drugs and profilaxis of viral infections. In particular, it will be described viruses of the following viral families: Parvoviridae, Poliomaviridae, Papillomaviridae, Adenoviridae, Herpesviridae, Poxviridae, Picornaviridae, Flaviviridae, Coronaviridae, Ortomixoviridae, Rabdoviridae, Retroviridae, Hepadnaviridae. In addition, introduction to applied virology will be provided (i.e., vaccine development, viral vectors and oncolytic viruses). Students will be able to apply the acquired knowledge to understand in-depth texts and experimental data related to the discipline.Core Documentation
All the detailed list of topics covered during the lessons, the PDF files of power point presentations used during the course and supplementary material for exam preparation are available in the Moodle platform of the course.Adopted text book:
- N. J. Dimmock, A. J. Easton, K. N. Leppard - Introduction to Modern Virology - Seventh edition 2016 -Wiley Blackwell - ISBN 978-1-119-97810-7
- Leonard Norkin – Virology: Molecular Biology and Pathogenesis - ASM (American Society for Microbiology) Press (this text book is more detailed)
Students are received at the end of the lessons or by appointment via email (elisabetta.affabris@uniroma3.it).
Type of delivery of the course
The course takes place with lectures, practical exercises in the classroom with the help of a PC and in an educational laboratory on setting up, application and maintenance of animal cell cultures. A site dedicated to the course on the MOODLE platform has been activated with the didactic materials and detailed program. Students can refer to the information present there registering on the platform. Attendance of the course is strongly recommended.Attendance
attendance of the course is strongly recommendedType of evaluation
Through an oral interview the learning of the discipline and its applications is evaluated, the student starts the exam discussing a topic chosen at will.