The course aim to provide a wider and deeper outlook of genetics topics not addressed in the course of genetics.
Special attention will be paied to the role of human genome (and epigenome) in the regulation of complex biological processes and in the individual response to endogenous and exogenous factors.
Special attention will be paied to the role of human genome (and epigenome) in the regulation of complex biological processes and in the individual response to endogenous and exogenous factors.
teacher profile teaching materials
- CELL CYCLE REGULATION, SENESCENCE AND APOPTOSIS. GENETIC OF AGING (GENETIC THEORIES OF AGING, GERONTOGENES AND GENES INVOLVED IN LONGEVITY, AGING IN ANIMAL MODELS, MOLECULAR AND CELLULAR AGING). CANCER GENETICS (ONCOGENES, ONCO-SUPPRESSOR GENES, CHROMOSOMAL REARRANGEMENTS INVOLVED IN CANCER, THE CANCER STEM CELLS THEORY). INDIVIDUAL GENETIC RESPONSE AND PHARMACOGENETICS.
- Scientific articles and teaching material provided by the teacher
Mutuazione: 20410599 Genetica molecolare in Biologia per la ricerca molecolare, cellulare e fisiopatologica LM-6 BERARDINELLI FRANCESCO
Programme
- GENOME (ORGANIZATION, STRUCTURAL GENOMICS, COMPARATIVE GENOMICS AND FUNCTUNIAL GENOMICS). EPIGENOME (METHYLATION, HISTONE CODE, CHROMATIN 3D ARCHITECTURE, NON-CODING RNA). EXAMPLES OF EPIGENETIC REGULATION: CELL DIFFERENTIATION AND GENETIC MECHANISMS OF SEX DETERMINATION (HOW DOES SEX IS GENETICALLY DETERMINED, INACTIVATION OF X CHROMOSOME, SEX-DEPENDENT PHONOTYPIC EFFECTS).- CELL CYCLE REGULATION, SENESCENCE AND APOPTOSIS. GENETIC OF AGING (GENETIC THEORIES OF AGING, GERONTOGENES AND GENES INVOLVED IN LONGEVITY, AGING IN ANIMAL MODELS, MOLECULAR AND CELLULAR AGING). CANCER GENETICS (ONCOGENES, ONCO-SUPPRESSOR GENES, CHROMOSOMAL REARRANGEMENTS INVOLVED IN CANCER, THE CANCER STEM CELLS THEORY). INDIVIDUAL GENETIC RESPONSE AND PHARMACOGENETICS.
Core Documentation
- HUMAN MOLECULAR GENETICS, Tom Strachan, Andrew Read, Zanichelli- Scientific articles and teaching material provided by the teacher
Type of delivery of the course
Lectures, classroom activities and laboratory practical experiences using fluorescence microscopes and advanced and specific analysis software.Type of evaluation
Oral examination. The exam consists of an interview of about 30 minutes during which the student will have to answer questions relating to the topics covered during the course. The evaluation will take into account the knowledge acquired, the student's ability to integrate the information acquired, and the property and clarity of the language used. Ongoing evaluation. There are two written tests in progress (optional) which can contribute to the final vote.