The course aims to provide students with fundamental knowledge on the basic principles of toxicology. In particular, the toxicodynamic and toxicokinetic mechanisms that are behind the toxic effects produced by different natural and synthesized xenobiotics, and the process of evaluation of toxicological risks will be analyzed. This knowledge will allow students to acquire specific professional skills useful in experimental and analytical research laboratories and to carry out professional activities in the pharmaco-toxicological field to protect the safety of the environment, food, cosmetic products and drugs, of both synthetic and natural origin.
teacher profile teaching materials
Areas of study and specialization in toxicology; Classification of toxic agents; Definition of unwanted effects induced by a xenobiotic; Significance of local and systemic toxicity; Interaction between multiple xenobiotics and toxic responses; Selectivity of the toxic effect; Exposure characteristics (dose, duration, frequency); dose-effect relationship; therapeutic index; safety margin; NOAEL, LOAEL, DL50; Toxicological studies; Mechanisms of interference of xenobiotics with physiological processes; Concepts and mechanisms underlying the processes of absorption, biotransformation, distribution and excretion of a xenobiotic; Risk and Toxicity: meaning and consequences; Evaluation and extrapolation of experimental toxicological data to humans.
Organ and system toxicology
Liver, renal, cardiovascular, skin and CNS toxicity.
Developmental toxicology
Principles of developmental toxicology. Critical periods of susceptibility and risk assessment. Pathogenetic mechanisms of developmental toxicity. Toxicokinetics in pregnancy. Toxicity to the mother and effects on embryo-foetal development (ethanol, methylmercury, lead, etc.).
Food toxicology
Bacterial toxins; mycotoxins; pesticides; additives; animal and plant toxins. Quality control issues (contamination, adulteration, adulteration)
Substances of abuse
Toxicity, abuse, dependence, withdrawal from: stimulants, depressants, psychedelic-hallucinogens. Smart drugs
Toxic effects of pesticides, metals, solvents
Clinical toxicology
General antidotism. Poisonings from: acids, alkalis, carbon monoxide, sulfur dioxide, nitrogen oxides, ozone, paracetamol, amphetamines, anticholinergics, cyanide, digitalis, ethanol, hydrocarbons, insecticides (chlorinated, organophosphorus and carbamate, botanical), herbicides, polychlorinated biphenyls, iron, mercury, opiates, phenothiazines, salicylates, hypnotics and sedatives, tricyclic antidepressants. Toxicity of over-the-counter products.
Power-point files of the lessons will be provided
To get an appointment with the Professor, email to: viviana.trezza@uniroma3.it
Mutuazione: 20402518 TOSSICOLOGIA in Biologia Molecolare, Cellulare e della Salute LM-6 N0 TREZZA VIVIANA
Programme
General principlesAreas of study and specialization in toxicology; Classification of toxic agents; Definition of unwanted effects induced by a xenobiotic; Significance of local and systemic toxicity; Interaction between multiple xenobiotics and toxic responses; Selectivity of the toxic effect; Exposure characteristics (dose, duration, frequency); dose-effect relationship; therapeutic index; safety margin; NOAEL, LOAEL, DL50; Toxicological studies; Mechanisms of interference of xenobiotics with physiological processes; Concepts and mechanisms underlying the processes of absorption, biotransformation, distribution and excretion of a xenobiotic; Risk and Toxicity: meaning and consequences; Evaluation and extrapolation of experimental toxicological data to humans.
Organ and system toxicology
Liver, renal, cardiovascular, skin and CNS toxicity.
Developmental toxicology
Principles of developmental toxicology. Critical periods of susceptibility and risk assessment. Pathogenetic mechanisms of developmental toxicity. Toxicokinetics in pregnancy. Toxicity to the mother and effects on embryo-foetal development (ethanol, methylmercury, lead, etc.).
Food toxicology
Bacterial toxins; mycotoxins; pesticides; additives; animal and plant toxins. Quality control issues (contamination, adulteration, adulteration)
Substances of abuse
Toxicity, abuse, dependence, withdrawal from: stimulants, depressants, psychedelic-hallucinogens. Smart drugs
Toxic effects of pesticides, metals, solvents
Clinical toxicology
General antidotism. Poisonings from: acids, alkalis, carbon monoxide, sulfur dioxide, nitrogen oxides, ozone, paracetamol, amphetamines, anticholinergics, cyanide, digitalis, ethanol, hydrocarbons, insecticides (chlorinated, organophosphorus and carbamate, botanical), herbicides, polychlorinated biphenyls, iron, mercury, opiates, phenothiazines, salicylates, hypnotics and sedatives, tricyclic antidepressants. Toxicity of over-the-counter products.
Core Documentation
Casarett & Doull’s Toxicology: The Basic Science of Poisons, 9th editionPower-point files of the lessons will be provided
To get an appointment with the Professor, email to: viviana.trezza@uniroma3.it
Type of delivery of the course
Class lecturesAttendance
Attendance is compulsoryType of evaluation
Two intercourse written assessments will be made, consisting of open questions and multiple-choice questions. The evaluation of each test will be in 30/30. Students who will get a score of at least 18 in each test will pass the exam, with a score corresponding to the average score of the two tests . Alternatively, students may also decide to have a single oral exam on the entire program of the course, with an overall evaluation in 30/30.