The Course aims to provide the student with advanced knowledge and skills in molecular biology of neurodevelopment, with particular reference to the central nervous system of vertebrates.
The aim of the first module is to provide the student with general knowledge about the cellular processes that lead, in the course of early and late embryogenesis, to the formation of the central nervous system from the neural tube. Advanced concepts on morphogenetic processes ensuring the achievement of the general cytoarchitecture of telecephalon, diencephalon, mesencephalon, metencephalon, myelencephalon and spinal cord will be provided. In particular, the student will acquire knowledge and skills on neuronal migration processes (under normal and pathological conditions) that lead to the layering of the cerebral cortex, spinal cord, and cerebellum. Advanced knowledge and expertise will also be provided on the cellular processes underlying adult neurogenesis and neurodegeneration, focusing on the role of apoptosis and autophagy. The student, through an interactive teaching will acquire skills in the study of pathological conditions, such as the most common neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Huntington's chorea).
The aim of the second module is to provide the student with general knowledge regarding the gene expression underlying the differentiation and morphogenesis of the nervous tissue. These molecular mechanisms will be addressed in different study models. It will be highlighted how neurogenesis and plasticity have profound functional implications in the nervous system throughout the life of the individual. The student, by means an interactive teaching, will acquire skills on new biomolecular technologies to study the development and functionality of the nervous system under physiological and pathological conditions.
The aim of the first module is to provide the student with general knowledge about the cellular processes that lead, in the course of early and late embryogenesis, to the formation of the central nervous system from the neural tube. Advanced concepts on morphogenetic processes ensuring the achievement of the general cytoarchitecture of telecephalon, diencephalon, mesencephalon, metencephalon, myelencephalon and spinal cord will be provided. In particular, the student will acquire knowledge and skills on neuronal migration processes (under normal and pathological conditions) that lead to the layering of the cerebral cortex, spinal cord, and cerebellum. Advanced knowledge and expertise will also be provided on the cellular processes underlying adult neurogenesis and neurodegeneration, focusing on the role of apoptosis and autophagy. The student, through an interactive teaching will acquire skills in the study of pathological conditions, such as the most common neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Huntington's chorea).
The aim of the second module is to provide the student with general knowledge regarding the gene expression underlying the differentiation and morphogenesis of the nervous tissue. These molecular mechanisms will be addressed in different study models. It will be highlighted how neurogenesis and plasticity have profound functional implications in the nervous system throughout the life of the individual. The student, by means an interactive teaching, will acquire skills on new biomolecular technologies to study the development and functionality of the nervous system under physiological and pathological conditions.
Mutuazione: 20410527 Neurobiologia molecolare dello sviluppo in Biologia Molecolare, Cellulare e della Salute LM-6 R MORENO SANDRA, ROSSI MARIANNA NICOLETTA
teacher profile teaching materials
2) Molecular pathways of polarity and segmentation. Molecular organizers of neurodevelopment. Determination and differentiation of neuronal cells. The anterior-posterior axis and Hox genes: characterization and role in anterior-posterior specification of the organism.
3) Axon growth and direction.
4) Long non-coding RNA and circRNA in brain development.
5) Role of regulatory RNAs in synaptic translational control.
6) Molecular mechanisms of adult neurogenesis.
7) Role of Polyamines in the modulation of glutamate receptors. Interaction between glutamatergic system, serotonergic system and polyamine metabolism.
8) Animal models used in neuronal diseases.
9) NGS techniques for the study of neurodevelopment
Mutuazione: 20410527 Neurobiologia molecolare dello sviluppo in Biologia Molecolare, Cellulare e della Salute LM-6 R MORENO SANDRA, ROSSI MARIANNA NICOLETTA
Programme
1) Genes and networks involved in neural induction with particular attention to the regulatory role of microRNAs.2) Molecular pathways of polarity and segmentation. Molecular organizers of neurodevelopment. Determination and differentiation of neuronal cells. The anterior-posterior axis and Hox genes: characterization and role in anterior-posterior specification of the organism.
3) Axon growth and direction.
4) Long non-coding RNA and circRNA in brain development.
5) Role of regulatory RNAs in synaptic translational control.
6) Molecular mechanisms of adult neurogenesis.
7) Role of Polyamines in the modulation of glutamate receptors. Interaction between glutamatergic system, serotonergic system and polyamine metabolism.
8) Animal models used in neuronal diseases.
9) NGS techniques for the study of neurodevelopment
Core Documentation
Lecture slides will be provided.Attendance
Attendance will be twice-weekly with two-hour lessons.Type of evaluation
Oral examination. The test is an interview of about 30 minutes and the student will present a study related to the course program through a Powerpoint presentation and will answer some questions on the topics covered during the course. Each vote takes into account the acquired knowledge (50%), the student's ability to integrate different concepts and insert them correctly in contextual problems (30%), and the ability to offer a clear language (20%).