The course aims to provide students with theoretical and experimental tools for the preparation, study, development and application of nanomaterials for biotechnologies, used in the field of environmental and health protection. Inorganic-based nanomaterials will be considered appropriately activated and functionalized with specific properties, such as diagnostic and sensory, transport of materials or substances, catalytic activity for production processes and transformation of resources, also with a view to sustainable development. The course also includes some laboratory experiences to provide practical manual skills and complementary skills. The laboratory will further refine the critical and analytical skills required for optimal design, preparation, chemical-physical characterization and application of functionalized inorganic nanomaterials in the field of biotechnology.
teacher profile teaching materials
Nanomaterials: definition and peculiarities. Types of nanomaterials (organic, inorganic, organic-inorganic hybrids). Importance of the surface in nanomaterials. Phenomena influenced by the surface. Thermodynamic aspects of nanometric phases. Hierarchical nanostructures. 1D and 2D nanomaterials. Introduction to band theory. Semiconductor nanomaterials and Quantum Dots. Electronic and spectroscopic properties. Luminescent Carbon Dots. Nanoparticles of noble metals and their plasmonic properties. Organic-inorganic nanocomposites. Multifunctional nanostructures that can be activated by external stimuli for diagnostics, drug-delivery and for curative treatments in nanomedicine. Synthesis of nanoparticles in solution with "green chemistry" methods. Strategies to obtain different porosities, dimensions and morphologies (nanospheres, nanocubes, nanorods, core@shell) of nanoparticles. Surface functionalization of inorganic nanoparticles. Chemical-physical analysis of nanostructures. Spectroscopic investigations : fluorescence, UV-vis-visible, NIR and infrared). Dynamic light scattering.
Laboratory (32-36 h)
1) Bottom up approach: synthesis of metallic nanoparticles (Au, Ag) in aqueous solution.
2) Top down approach: preparation of polymer nanoparticles
3) Functionalization
4) Spectroscopic characterization of the nanoparticles prepared in the optical field: UV-vis and and FTIR.
5) Investigation of colloidal properties.
D. Vollath; Nanoparticles-nanocomposites-nanomaterials. An Introduction fo Beginners
Material will also be provided by the teacher
Programme
Theory (3 CFU = 24h)Nanomaterials: definition and peculiarities. Types of nanomaterials (organic, inorganic, organic-inorganic hybrids). Importance of the surface in nanomaterials. Phenomena influenced by the surface. Thermodynamic aspects of nanometric phases. Hierarchical nanostructures. 1D and 2D nanomaterials. Introduction to band theory. Semiconductor nanomaterials and Quantum Dots. Electronic and spectroscopic properties. Luminescent Carbon Dots. Nanoparticles of noble metals and their plasmonic properties. Organic-inorganic nanocomposites. Multifunctional nanostructures that can be activated by external stimuli for diagnostics, drug-delivery and for curative treatments in nanomedicine. Synthesis of nanoparticles in solution with "green chemistry" methods. Strategies to obtain different porosities, dimensions and morphologies (nanospheres, nanocubes, nanorods, core@shell) of nanoparticles. Surface functionalization of inorganic nanoparticles. Chemical-physical analysis of nanostructures. Spectroscopic investigations : fluorescence, UV-vis-visible, NIR and infrared). Dynamic light scattering.
Laboratory (32-36 h)
1) Bottom up approach: synthesis of metallic nanoparticles (Au, Ag) in aqueous solution.
2) Top down approach: preparation of polymer nanoparticles
3) Functionalization
4) Spectroscopic characterization of the nanoparticles prepared in the optical field: UV-vis and and FTIR.
5) Investigation of colloidal properties.
Core Documentation
S. M. Lindsay; Introduction to Nanoscience; OxfordD. Vollath; Nanoparticles-nanocomposites-nanomaterials. An Introduction fo Beginners
Material will also be provided by the teacher
Reference Bibliography
Nanostructured Materials based on Noble Metals for Advanced Biological Applications” Editor Iole Venditti Ed. MDPI ISBN 978-3-03928-833-5 (Pbk); ISBN 978-3-03928-834-2 https://doi.org/10.3390/books978-3-03928-834-2 (registering DOI) © 2020 by the authors; CC BY licence Pages: 124; Published: June 2020 (This book is a printed edition of the Special Issue Nanostructured Materials based on Noble Metals for Advanced Biological Applications that was published in Nanomaterials) “Advances in macromolecules: perspectives and applications” Editor M.V. Russo ( 325 pp, February 2010) Ed. Spinger UK ISBN: 978-90-481-3191-4; Iole Venditti is Co-author of Chapter 1: Nanostructured Macromolecules.Type of delivery of the course
Frontal teaching, and laboratory. In case of Covid emergency extension, will be evaluated the possibility of distance learning.Attendance
frontal and laboratory teaching (in presence)Type of evaluation
The exam will be oral, with questions on the various topics of the Teaching. Particular attention will also be paid to the mastery of the concepts, methods, tools and techniques used in the laboratory experiences. For the laboratory part, a written paper is required concerning the methods and results obtained during the experiences.