The aim of the course is to introduce students to the “inorganic biofactors”, starting from their biochemical role to the analysis of their impact on human health.
Moreover, the course will provide student the essential knowledge for understanding of the biochemical and molecular mechanism underlying metabolic, mitochondrial and neoplastic diseases.
Moreover, the course will provide student the essential knowledge for understanding of the biochemical and molecular mechanism underlying metabolic, mitochondrial and neoplastic diseases.
teacher profile teaching materials
Support texts:
Siliprandi & Tettamanti "Biochimica Medica - strutturale, metabolica e funzionale" Ed. Piccin
- Chiurchiù & Maccarrone "I radicali liberi e la loro rilevanza in biomedicina: dai meccanismi molecolari alle prospettive terapeutiche" Ed Piccin
RECEPTION TIME: Mondays 10 am (please fix an appointment, alessandra.dimasi@uniroma3.it)
Programme
HEMOPROTEINS. HEME METABOLISM AND ASSOCIATED DISEASES. HEME BIOSYNTHESIS AND ASSOCIATED DISEASES. IRON METABOLISM AND ASSOCIATED DISEASES. DEFINITION OF “INORGANIC BIOFACTORS.” THE MAIN “INORGANIC BIOFACTORS”: MOLECULAR OXYGEN, CARBON MONOXIDE, NITRIC OXIDE, HYDROGEN SULFIDE. ANALYSIS OF THE BIOCHEMICAL AND CELLULAR ROLE OF “INORGANIC BIOFACTORS” AND THEIR CONTRIBUTION TO THE ONSET OF HUMAN DISEASES. THERAPEUTIC ROLE OF “INORGANIC BIOFACTORS”. REACTIVE OXYGEN AND NITROGEN SPECIES. MITOCHONDRIAL DISEASES. THE ENERGY QUESTION IN CANCER CELLS. METABOLIC CHANGES IN CANCER CELLS: THE WARBURG EFFECT AND THE REVERSE WARBURG EFFECT. RELATIONSHIP BETWEEN METABOLISM, POST-TRANSLATIONAL MODIFICATIONS OF PROTEINS, AND EPIGENETICS. RELATIONSHIP BETWEEN ENERGY METABOLISM AND GENOME STABILITY.Prerequisiti
Knowledge of the basic principles of general, inorganic and organic chemistry, structural biochemistry and enzymology.Core Documentation
SCIENTIFIC PAPERS SUPPLIED BY THE TEACHER.Support texts:
Siliprandi & Tettamanti "Biochimica Medica - strutturale, metabolica e funzionale" Ed. Piccin
- Chiurchiù & Maccarrone "I radicali liberi e la loro rilevanza in biomedicina: dai meccanismi molecolari alle prospettive terapeutiche" Ed Piccin
RECEPTION TIME: Mondays 10 am (please fix an appointment, alessandra.dimasi@uniroma3.it)
Type of delivery of the course
The course of Cellular Biochemistry is a theoretical course that takes place in the second semester (March-May) of the first year and is divided into 4 hours of lectures per week with the use of PowerPoint presentations. Lessons will be provided both in person and on a telematic platform depending on the pandemic situation.Attendance
Optional.Type of evaluation
The exam consists of a non-mandatory written test (pre-exam session) that will take place after the Christmas break. If you do not take the written test, or if you wish to improve the grade you received on the written test, you may take the oral exam on the scheduled exam dates. The written exam will consist of three parts, for a total of 17 questions and a maximum score of 31 points: Part A – Multiple-choice questions: 12 questions, each worth 1 point, for a maximum of 12 points. Part B – Short-answer questions: 3 questions, each worth 3 points, for a maximum of 9 points. Part C – Reasoning questions: 2 questions, each worth 5 points, for a maximum of 10 points. The final grade will evaluate the following parameters: a) Appropriateness, correctness, and congruity of acquired knowledge and skills; b) appropriate use of the specific language of the discipline; c) Expressive capacity; d) Logical skills; e) Synthesis skills; f) Ability to link different topics. Consequently, the judgment could be: a) Sufficient (from 18 to 20/30) b) Fair (from 21 to 23) c) Voucher (from 24 to 26) d) Excellent (from 27 to 29) e) Excellent (30) Praise is attributed to candidates clearly above the average, and whose possible notional, expressive, conceptual and logical limits are altogether irrelevant.