The course aims at giving:
⁃ a general knowledge of the biosynthetic pathways of secondary metabolism;
⁃ information about the main natural products derived from microorganism, plants and animals and their role in natural environment;
⁃ knowledge on the structure/biological activity relationship of the main secondary metabolites used in pharmaceutical and healthcare industry.
⁃ a general knowledge of the biosynthetic pathways of secondary metabolism;
⁃ information about the main natural products derived from microorganism, plants and animals and their role in natural environment;
⁃ knowledge on the structure/biological activity relationship of the main secondary metabolites used in pharmaceutical and healthcare industry.
teacher profile teaching materials
Acetate pathway. Prostaglandins, aromatic polyketides, anthraquinones, cannabinoids, aflatoxins.
Shikimate pathway. Shikimic acid biosynthesis. Cinnamic acids. Lignins. Phenylpropanoids. Benzoic acids. Coumarins. Flavonoids. Tannins. Isoflavones. Terpenoid quinones.
Mevalonate pathway. Mevalonic acid biogenesis. Biosynthesis of different classes of terpenes. Iridoids. Gibberellins. Triterpenes. Squalene, Cholesterol. Hormones. Animal and human steroids. Phytosterols.
Alkaloids: definition and nomenclature. Biosynthesis and biological activity of the main classes of natural alkaloids: cocaine, nicotine, curare, morphine, loganin, lysergic acid, coniine.
Carbohydrates: generalities. Cyanogenic glycosides. Streptomycins.
Peptidic secondary metabolites. Interferons. Opioid peptides. Peptide toxins: ricin and botulin. Penicillins.
P.M. Dewick : Medicinal natural products. A biosynthetic approach. Third edition.
Programme
Introduction to natural products chemistry. Main features of secondary metabolism.Acetate pathway. Prostaglandins, aromatic polyketides, anthraquinones, cannabinoids, aflatoxins.
Shikimate pathway. Shikimic acid biosynthesis. Cinnamic acids. Lignins. Phenylpropanoids. Benzoic acids. Coumarins. Flavonoids. Tannins. Isoflavones. Terpenoid quinones.
Mevalonate pathway. Mevalonic acid biogenesis. Biosynthesis of different classes of terpenes. Iridoids. Gibberellins. Triterpenes. Squalene, Cholesterol. Hormones. Animal and human steroids. Phytosterols.
Alkaloids: definition and nomenclature. Biosynthesis and biological activity of the main classes of natural alkaloids: cocaine, nicotine, curare, morphine, loganin, lysergic acid, coniine.
Carbohydrates: generalities. Cyanogenic glycosides. Streptomycins.
Peptidic secondary metabolites. Interferons. Opioid peptides. Peptide toxins: ricin and botulin. Penicillins.
Core Documentation
Slides of the lessons and additional material are available on line.P.M. Dewick : Medicinal natural products. A biosynthetic approach. Third edition.
Attendance
Attendance is not mandatory but is strongly recommended.Type of evaluation
Preparation and oral presentation of a PowerPoint presentation on a natural substance selected by mutual agreement between the professor and the student.