Prof.ssa ELISABETTA AFFABRIS

QualificaProfessore Ordinario
Settore Scientifico DisciplinareBIO/19
Telefono0657336341
Cellulare aziendale87672
Emailelisabetta.affabris@uniroma3.it
IndirizzoViale Guglielmo Marconi 446
Struttura/Afferenza
  • Dipartimento di Scienze
Cariche e responsabilità
  • Titolare Di Incarico rettorale per il coordinamento delle campagne di informazione sul rischio AIDS
Altre informazioniSito web personale
Curriculum
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Profilo INSEGNAMENTI Prodotti della ricerca Avvisi Ricevimento e materiale didattico

Contributo in Rivista

  • Inhibition by Thyroid Hormones of Cell Migration Activated by IGF-1 and MCP-1 in THP-1 Monocytes: Focus on Signal Transduction Events Proximal to Integrin αvβ3, CANDELOTTI, ELENA; MAIOLO, MARIANGELA; GIONFRA, FABIO; PERCARIO, ZULEMA ANTONIA; POLTICELLI, FABIO; PERSICHINI, TIZIANA; COLASANTI, MARCO; AFFABRIS, ELISABETTA; INCERPI, SANDRA, , 2021Link identifier #identifier_person_159335-1 Dettaglio
  • Thyroid Hormones Interaction With Immune Response, Inflammation and Non-thyroidal Illness Syndrome, GIONFRA, FABIO; PERCARIO, ZULEMA ANTONIA; AFFABRIS, ELISABETTA; INCERPI, SANDRA, , 2021Link identifier #identifier_person_132700-2 Dettaglio
  • An emerging interplay between extracellular vesicles and cytokines, AIELLO, ALESSANDRA; GIANNESSI, FLAVIA; PERCARIO, ZULEMA ANTONIA; AFFABRIS, ELISABETTA, , 2020Link identifier #identifier_person_159350-3 Dettaglio
  • Introduction to the special issue: Extracellular vesicles and biological signal delivery in the inflammatory microenvironment, AFFABRIS, ELISABETTA; MANGINO, GIORGIO, , 2020Link identifier #identifier_person_125104-4 Dettaglio
  • The role of extracellular vesicles as allies of HIV, HCV and SARS viruses, GIANNESSI, FLAVIA; AIELLO, ALESSANDRA; FRANCHI, FRANCESCA; PERCARIO, ZULEMA ANTONIA; AFFABRIS, ELISABETTA, , 2020Link identifier #identifier_person_113753-5 Dettaglio
  • Purification and Characterization of Antibodies in Single-Chain Format against the E6 Oncoprotein of Human Papillomavirus Type 16, PERCARIO, ZULEMA ANTONIA; AFFABRIS, ELISABETTA, , 2018Link identifier #identifier_person_162006-6 Dettaglio
  • The involvement of plasmacytoid cells in HIV infection and pathogenesis., AIELLO, ALESSANDRA; GIANNESSI, FLAVIA; PERCARIO, ZULEMA ANTONIA; AFFABRIS, ELISABETTA, , 2018Link identifier #identifier_person_193533-7 Dettaglio
  • Staphylococcus aureus esx factors control human dendritic cell functions conditioning Th1/Th17 response, CRUCIANI, MELANIA; PERCARIO, ZULEMA ANTONIA; RIZZO, FABIANA; BRANDI, VALENTINA; POLTICELLI, FABIO; AFFABRIS, ELISABETTA, , 2017Link identifier #identifier_person_74325-8 Dettaglio
  • A novel intracellular antibody against the E6 oncoprotein impairs growth of human papillomavirus 16-positive tumor cells in mouse models, PERCARIO, ZULEMA ANTONIA; AFFABRIS, ELISABETTA, , 2016Link identifier #identifier_person_118751-9 Dettaglio
  • HIV-1 Myristoylated Nef Treatment of Murine Microglial Cells Activates Inducible Nitric Oxide Synthase, NO2 Production and Neurotoxic Activity, MANGINO, GIORGIO; FAMIGLIETTI, MARYLINDA; CAPONE, CATERINA; PERCARIO, ZULEMA ANTONIA; LEONE, STEFANO; PERSICHINI, TIZIANA; AFFABRIS, ELISABETTA, , 2015Link identifier #identifier_person_100789-10 Dettaglio
  • Nef, the shuttling molecular adaptor of HIV, influences the cytokine network, PERCARIO, ZULEMA ANTONIA; ALI, MUHAMMAD; MANGINO, GIORGIO; AFFABRIS, ELISABETTA, , 2015Link identifier #identifier_person_41128-11 Dettaglio
  • Role of the microenvironment in tumourigenesis: focus on virus-induced tumors, MANGINO, GIORGIO; AFFABRIS, ELISABETTA, , 2015Link identifier #identifier_person_82691-12 Dettaglio
  • Exosomes from human immunodeficiency virus type 1 (HIV-1)-infected cells license quiescent CD4+ T lymphocytes to replicate HIV-1 through a Nef- and ADAM17-dependent mechanism., ARENACCIO, CLAUDIA; AFFABRIS, ELISABETTA, , 2014Link identifier #identifier_person_188890-13 Dettaglio
  • In vivo antitumor effect of an intracellular single-chain antibody fragment against the E7 oncoprotein of human papillomavirus 16., PERCARIO, ZULEMA ANTONIA; AFFABRIS, ELISABETTA, , 2014Link identifier #identifier_person_141063-14 Dettaglio
  • Effect of atrial natriuretic peptide on reactive oxygen species-induced by hydrogen peroxide in THP-1 monocytes: role in cell growth, migration and cytokine release., INCERPI, SANDRA; AFFABRIS, ELISABETTA, , 2013Link identifier #identifier_person_53191-15 Dettaglio
  • Cancer Regulator MicroRNA: Potential Relevance in Diagnosis, Prognosis and Treatment of Cancer., MANGINO, GIORGIO; PERCARIO, ZULEMA ANTONIA; AFFABRIS, ELISABETTA, , 2012Link identifier #identifier_person_104117-16 Dettaglio
  • Exogenous Nef Induces Proinflammatory SignalingEvents in Murine Macrophages, MANGINO, GIORGIO; SERRA, VALERIA; PERCARIO, ZULEMA ANTONIA; AFFABRIS, ELISABETTA, , 2012Link identifier #identifier_person_85617-17 Dettaglio
  • Interferon-β Induces Cellular Senescence in Cutaneous Human Papilloma Virus-Transformed Human Keratinocytes by Affecting p53 Transactivating Activity., PERCARIO, ZULEMA ANTONIA; AFFABRIS, ELISABETTA, , 2012Link identifier #identifier_person_84890-18 Dettaglio
  • Nongenomic effects of thyroid hormones on the immune system cells: new targets, old players, AFFABRIS, ELISABETTA; INCERPI, SANDRA, , 2012Link identifier #identifier_person_3194-19 Dettaglio
  • HIV-1 Nef Induces Proinflammatory State in Macrophages through Its Acidic Cluster Domain: Involvement of TNF Alpha Receptor Associated Factor 2, PERCARIO, ZULEMA ANTONIA; ACCONCIA, FILIPPO; CHIARABELLI, CRISTIANO; LEONE, STEFANO; NOTO, ALESSIA; POLTICELLI, FABIO; AFFABRIS, ELISABETTA, , 2011Link identifier #identifier_person_176667-20 Dettaglio
  • HMGB1 and cord blood: its role as immuno-adjuvant factor in innate immunity, PERCARIO, ZULEMA ANTONIA; AFFABRIS, ELISABETTA, , 2011Link identifier #identifier_person_125668-21 Dettaglio
  • The conserved acidic cluster domain of HIV-1 Nef is required to induces a proinflammatory state in primary macrophages: involvement of TNF alpha Receptor Associated Factor 2, CHIARABELLI, CRISTIANO, , 2011Link identifier #identifier_person_170041-22 Dettaglio
  • Astrocytes contacting HIV-1-infected macrophages increase the release of CCL2 in response to the HIV-1-dependent enhancement of membrane-associated TNFalpha in macrophages, AFFABRIS, ELISABETTA, , 2010Link identifier #identifier_person_18810-23 Dettaglio
  • Immunomodulatory activity of a plant extract containing human papillomavirus 16-E7 protein in human monocyte-derived dendritic cells, AFFABRIS, ELISABETTA, , 2009Link identifier #identifier_person_163238-24 Dettaglio
  • Senescence and cell death pathways and their role in cancer therapeutic outcome, AFFABRIS, ELISABETTA, , 2009Link identifier #identifier_person_177112-25 Dettaglio
  • In vitro treatment of human monocyte/macrophages with myristoylated recombinant Nef of HIV 1 leads to the activation of Mitogen-Activated Protein Kinases, IkB kinases and Interferon Regulatory Factor 3 and to the release of beta Interferon, AFFABRIS, ELISABETTA, , 2007Link identifier #identifier_person_25405-26 Dettaglio
  • Perspectives in biomolecular therapeutic intervention in cancer: from the early to the new strategies with type I interferons, AFFABRIS, ELISABETTA, , 2007Link identifier #identifier_person_84596-27 Dettaglio
  • TNF-related apoptosis-inducing ligand (TRAIL) as a pro-apoptotic signal transducer with cancer therapeutic potential., PERCARIO, ZULEMA ANTONIA; AFFABRIS, ELISABETTA, , 2005Link identifier #identifier_person_69368-28 Dettaglio
  • TRAIL as a pro-apoptotic signal transducer with cancer therapeutic potential, AFFABRIS, ELISABETTA, , 2005Link identifier #identifier_person_185688-29 Dettaglio
  • TRAIL is a key target in S-phase slowing-dependent apoptosis induced by Interferon-beta in cervical carcinoma cells, AFFABRIS, ELISABETTA, , 2005Link identifier #identifier_person_150666-30 Dettaglio
  • HIV-1 Nef Activates STAT3 in Primary Human Monocyte/Macrophages through the Release of Soluble Factors: Involvement of Nef Domains Interacting with the Cell Endocytotic Machinery, AFFABRIS, ELISABETTA, , 2003Link identifier #identifier_person_111210-31 Dettaglio
  • HIV-1 Nef Induces the Release of Inflammatory Factors from Human Monocyte/Macrophages: Involvement of Nef Endocytotic Signals and NF-kB Activation, AFFABRIS, ELISABETTA, , 2003Link identifier #identifier_person_145032-32 Dettaglio
  • Review:IRF-1 as a negative regulator of cell proliferation, AFFABRIS, ELISABETTA, , 2002Link identifier #identifier_person_83374-33 Dettaglio
  • HIV-1 Nef activates STAT1 in human monocytes/macrophages through the release of soluble factors, AFFABRIS, ELISABETTA, , 2001Link identifier #identifier_person_70569-34 Dettaglio
  • Interferon beta induces S-phase slowing via up-regulated expression of PML in squamous carcinoma cells, AFFABRIS, ELISABETTA, , 2000Link identifier #identifier_person_70144-35 Dettaglio
  • Retinoic acid is able to induce IRF-1 in squamous carcinoma cells via a STAT-1 independent signalling pathway, AFFABRIS, ELISABETTA, , 1999Link identifier #identifier_person_197118-36 Dettaglio
  • Antiproliferative activity of interferon alfa and retinoic acid in SiHa carcinoma cells: the role of cell adhesion, AFFABRIS, ELISABETTA, , 1998Link identifier #identifier_person_32584-37 Dettaglio
  • Apoptosis and growth inhibition of squamous carcinoma cells treated with IFN-alfa, IFN-beta and retinoic acid are associated with induction of the cyclin-dependent kinase inhibitor p21, AFFABRIS, ELISABETTA, , 1998Link identifier #identifier_person_63685-38 Dettaglio
  • Retinoic acid and interferon inhibition of cell proliferation is associated with apoptosis in squamous carcinoma cell lines. Role of IRF-1 and TGAseII-dependent pathways, AFFABRIS, ELISABETTA, , 1997Link identifier #identifier_person_71451-39 Dettaglio
  • Perspectives in interferon and cytokine research., AFFABRIS, ELISABETTA, , 1996Link identifier #identifier_person_151326-40 Dettaglio
  • Hemin inhibits the interferon beta-induced antiviral state in established cell lines, AFFABRIS, ELISABETTA, , 1995Link identifier #identifier_person_164466-41 Dettaglio
  • IFN-alpha2b and retinoic acid combined treatment affects proliferation and gene expression of human cervical carcinoma cells, AFFABRIS, ELISABETTA, , 1995Link identifier #identifier_person_112570-42 Dettaglio
  • Inhibition of protein phosphorylation blocks interferon-induced gene expression and modulates expression of the JAK family protein tyrosine kinases, AFFABRIS, ELISABETTA, , 1995Link identifier #identifier_person_34025-43 Dettaglio
  • Staurosporine inhibits interferon alpha-induced gene expression in Friend erythroleukemia cells through a PKC independent pathway., AFFABRIS, ELISABETTA, , 1995Link identifier #identifier_person_153364-44 Dettaglio
  • ACUTE REJECTION OF INTERFERON-TREATED LEUKEMIA-CELLS INJECTED INTO LETHALLY IRRADIATED SYNGENEIC MICE, AFFABRIS, ELISABETTA, , 1993Link identifier #identifier_person_53642-45 Dettaglio
  • Friend virus-induced erythroleukemia: a model system to study erythroid differentiation and leukemia development, AFFABRIS, ELISABETTA, , 1993Link identifier #identifier_person_87208-46 Dettaglio
  • Modulation of ferritin H-chain expression in Friend erythroleukemia cells: transcriptional and translational regulation by hemin, AFFABRIS, ELISABETTA, , 1992Link identifier #identifier_person_57490-47 Dettaglio
  • TRANSCRIPTIONAL INDUCTION OF H2 (CLASS-I) ANTIGENS AND BETA-2 MICROGLOBULIN BY INTERFERON-GAMMA IN INTERFERON-SENSITIVE AND INTERFERON-RESISTANT FRIEND-LEUKEMIA CELLS, AFFABRIS, ELISABETTA, , 1992Link identifier #identifier_person_139251-48 Dettaglio
  • Intracellular heme coordinately modulates globin chains synthesis, transferrin receptor number and ferritin content in differentiating Friend erythroleukemia cells, AFFABRIS, ELISABETTA, , 1991Link identifier #identifier_person_172089-49 Dettaglio
  • Positive modulation of hemoglobin, heme and transferrin receptor synthesis by murine interferons-alpha and -beta in differentiating Friend cells: pivotal role of heme synthesis, AFFABRIS, ELISABETTA, , 1991Link identifier #identifier_person_60675-50 Dettaglio
  • Post-transcriptional regulation of interferon-beta expression in erythroid Friend cells treated with interferon-gamma, AFFABRIS, ELISABETTA, , 1991Link identifier #identifier_person_115926-51 Dettaglio
  • Protein binding to the interferon response enhancer correlates with interferon-induction of 2-5A synthetase in normal and interferon-resistant Friend cells, AFFABRIS, ELISABETTA, , 1991Link identifier #identifier_person_97765-52 Dettaglio
  • A full-lenght murine 2-5A synthetase cDNA transfected in NIH-3T3 cells impairs EMCV but not VSV replication, AFFABRIS, ELISABETTA, , 1990Link identifier #identifier_person_30725-53 Dettaglio
  • Spectrum of biological activity of IFNs. In: "Lymphokines and interferons: from molecular biology to clinical trials", AFFABRIS, ELISABETTA, , 1990Link identifier #identifier_person_134727-54 Dettaglio
  • Interferons and differentiation of Friend cells, AFFABRIS, ELISABETTA, , 1989Link identifier #identifier_person_61011-55 Dettaglio
  • Poly (ADP-ribose) polymerase activity is inhibited by 2'-5'-oligoadenylates in mouse L-cells, AFFABRIS, ELISABETTA, , 1989Link identifier #identifier_person_7845-56 Dettaglio
  • Interferons and oncogenes in the control of cell growth and differentiation: working hypothesis and experimental facts, AFFABRIS, ELISABETTA, , 1988Link identifier #identifier_person_160124-57 Dettaglio
  • Interferons-alpha,beta and gamma-resistant Friend cell variants exhibiting receptor sites for Interferons but no induction of 2-5A synthetase and 67K protein kinase, AFFABRIS, ELISABETTA, , 1988Link identifier #identifier_person_145598-58 Dettaglio
  • MONOCLONAL-ANTIBODIES ANTI-MURINE INTERFERON (IFN) BETA-NEUTRALIZE THE STIMULATION OF ERYTHROID-DIFFERENTIATION INDUCED BY TREATMENT OF FRIEND-CELLS WITH DIMETHYLSULFOXIDE AND MURINE FIBROBLAST IFN, AFFABRIS, ELISABETTA, , 1988Link identifier #identifier_person_77204-59 Dettaglio
  • Opposite effects of murine interferons on erythroid differentiation of Friend cells, AFFABRIS, ELISABETTA, , 1988Link identifier #identifier_person_145820-60 Dettaglio
  • Effect of mouse interferon alpha/beta on the expression of H-2 (class I) antigens and on the levels of 2'-5' oligoadenylate synthetase activity in interferon-sensitive and interferon-resistant Friend leukemia cell tumors in mice., AFFABRIS, ELISABETTA, , 1987Link identifier #identifier_person_96272-61 Dettaglio
  • MOLECULAR MECHANISMS OF ACTION OF INTERFERONS IN THE FRIEND VIRUS-INDUCED LEUKEMIA-CELL SYSTEM, AFFABRIS, ELISABETTA, , 1987Link identifier #identifier_person_188406-62 Dettaglio
  • 2',5'-oligoadenylate synthetase-uninducible alpha, beta interferon-resistant Friend cells develop an antiviral state when permeabilized with lysolecithin and treated with 2',5'- oligoadenylate oligomers, AFFABRIS, ELISABETTA, , 1986Link identifier #identifier_person_90860-63 Dettaglio
  • Establishment of the antiviral state in alpha, beta interferon-resistant Friend cells treated with gamma interferon: induction of 67K protein kinase activity in absence of detectable 2-5A synthetase, AFFABRIS, ELISABETTA, , 1985Link identifier #identifier_person_179638-64 Dettaglio
  • Subcellular distribution of 2'-5'-oligoadenylate synthetase in differentiating Friend leukemia cells, AFFABRIS, ELISABETTA, , 1985Link identifier #identifier_person_58984-65 Dettaglio
  • The role of two interferon-induced enzymatic activities in erythroid differentiation of Friend cells., AFFABRIS, ELISABETTA, , 1985Link identifier #identifier_person_160996-66 Dettaglio
  • Role of interferon and 2'-5'-olygoadenylate synthetase in erythroid differentiation of Friend leukemia cells, AFFABRIS, ELISABETTA, , 1984Link identifier #identifier_person_176764-67 Dettaglio
  • 2-5A synthetase activity does not increase in interferon-resistent Friend leukemia cell variants treated with alpha/beta interferon despite the presence of high-affinity interferon receptor sites, AFFABRIS, ELISABETTA, , 1983Link identifier #identifier_person_91559-68 Dettaglio
  • Isolation of interferon-resistant variants of Friend erythroleukemia cells: effects of interferon and ouabain, AFFABRIS, ELISABETTA, , 1982Link identifier #identifier_person_24690-69 Dettaglio
  • Modulation of erythroid differentiation induced by DMSO in Friend cells treated with interferon: a clonal analysis, AFFABRIS, ELISABETTA, , 1982Link identifier #identifier_person_48224-70 Dettaglio
  • Interactions of interferon with in vitro model systems involved in hematopoietic cell differentiation., AFFABRIS, ELISABETTA, , 1980Link identifier #identifier_person_42894-71 Dettaglio
  • Erythroid differentiation of Friend erythroleukemia cells: a "variant" cell line endowed with an early expression of erythroid markers., AFFABRIS, ELISABETTA, , 1978Link identifier #identifier_person_189147-72 Dettaglio

Libro

  • Link identifier #identifier_person_160786-73Dettaglio

Contributo in volume e atti di convegno

  • PERCARIO, ZULEMA ANTONIA; MANGINO, GIORGIO; GALLO, VALENTINA; AFFABRIS, ELISABETTA, HIV-1 Nef Transfer and Intracellular Signalling in Uninfected Cells.(part 1, Chapter 3), vol. unico, pp. 61 78, 2011 Link identifier #identifier_person_76910-74Dettaglio
  • AFFABRIS, ELISABETTA, Antiproliferative effect of interferon beta in mucosal and cutaneous Human Papilloma Virus (HPV) - transformed keratinocytes., CYTOKINE, issn 1043-4666, vol. 43, pp. 330 330, 2008 Link identifier #identifier_person_142520-75Dettaglio
  • PERCARIO, ZULEMA ANTONIA; MANGINO, GIORGIO; LEONE, STEFANO; AFFABRIS, ELISABETTA, Recombinant myristoylated HIV-1 Nef protein is able to enter human primary macrophages and monocitic cell line THP-1 activating signal transduction events through a IRAK1 degradation – independent mechanism., 2008 Link identifier #identifier_person_14436-76Dettaglio
  • MANGINO, GIORGIO; PERCARIO, ZULEMA ANTONIA; LEONE, STEFANO; LAURO, GIULIANA MARIA; AFFABRIS, ELISABETTA, Recombinant Nef protein induces inflammatory response and upregulation of inducible nitric oxide synthase expression in the murine microglial cell line BV-2., 2008 Link identifier #identifier_person_164109-77Dettaglio
  • PERCARIO, ZULEMA ANTONIA; MANGINO, GIORGIO; AFFABRIS, ELISABETTA, The production of interferon-ß induced by HIV-1 Nef treatment of primary human monocyte-derived macrophages requires the PI3K/Akt pathway., 2008 Link identifier #identifier_person_19-78Dettaglio
  • AFFABRIS, ELISABETTA, Virus-cell interactions in Human Immunodeficiency Virus infection: recent advances in viral accessory proteins function., 2008 Link identifier #identifier_person_153678-79Dettaglio
  • AFFABRIS, ELISABETTA, In vitro treatment of human monocyte-derived macrophages with HIV-1 protein Nef activates cellular signaling pathways leading to type I Interferon production, vol. Unico, pp. 105 111, 2006 Link identifier #identifier_person_136206-80Dettaglio